Conditional analysis of the major histocompatibility complex in rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Conditional analysis of the major histocompatibility complex in rheumatoid arthritis
We performed a whole-genome association study of rheumatoid arthritis susceptibility using Illumina 550k single-nucleotide polymorphism (SNP) genotypes of 868 cases and 1194 controls from the North American Rheumatoid Arthritis Consortium (NARAC). Structured association analysis with adjustment for potential population stratification yielded 200 SNPs with p < 1 x 10-8 for association with RA, a...
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SIR, Within a single decade the research on complex diseases such as RA has changed from hypothesis-driven genetic studies to discovery-driven genome-wide association studies, and presently the field is moving further to the evaluation of dysfunctions in multiple systems and changes at different levels, such as epigenetics, transcriptomics, proteomics and metabolomics. A key issue in discovery-...
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15 صفحه اولMajor Histocompatibility Complex Class I–Recognizing Receptors Are Disease Risk Genes in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a heterogeneous syndrome of which a subset of patients develops vascular inflammation. The genetic determinants that confer risk for rheumatoid vasculitis are not known, but patients with vascular complications are known to have an expansion of CD4(+)CD28(null) T cells, a cell population potentially involved in endothelial damage. CD4(+)CD28(null) T cell clones isol...
متن کاملMajor histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis
Genotypic variability based genome-wide association studies (vGWASs) can identify potentially interacting loci without prior knowledge of the interacting factors. We report a two-stage approach to make vGWAS applicable to diseases: firstly using a mixed model approach to partition dichotomous phenotypes into additive risk and non-additive environmental residuals on the liability scale and secon...
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2009
ISSN: 1753-6561
DOI: 10.1186/1753-6561-3-s7-s36